Complexities of cerebral small vessel disease, blood pressure, and dementia relationship: new insights from genetics.

ABSTRACT:

Importance

There is increasing recognition that vascular disease, which can be treated, is a key contributor to dementia risk. However, the contribution of specific markers of vascular disease is unclear and, as a consequence, optimal prevention strategies remain unclear.

Objective

To disentangle the causal relation of several key vascular traits to dementia risk: (i) white matter hyperintensity (WMH) burden, a highly prevalent imaging marker of covert cerebral small vessel disease (cSVD); (ii) clinical stroke; and (iii) blood pressure (BP), the leading risk factor for cSVD and stroke, for which efficient therapies exist. To account for potential epidemiological biases inherent to late-onset conditions like dementia.

Design setting and participants

This study first ex

SUBMITTER: Sargurupremraj M 

PROVIDER: S-EPMC10543241 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature