EYA4 promotes breast cancer progression and metastasis through its role in replication stress avoidance.

ABSTRACT: The Eyes Absent (EYA) family of proteins is an atypical group of four dual-functioning protein phosphatases (PP), which have been linked to many vital cellular processes and organogenesis pathways. The four family members of this PP family possess transcriptional activation and phosphatase functions, with serine/threonine and tyrosine phosphatase domains. EYA4 has been associated with several human cancers, with tumor-suppressing and tumor-promoting roles. However, EYA4 is the least well-characterized member of this unique family of PP, with its biological functions and molecular mechanisms in cancer progression, particularly in breast cancer, still largely unknown. In the present study, we found that the over-expression of EYA4 in breast tissue leads to an aggressive and invasive breast c

SUBMITTER: de la Pena Avalos B 

PROVIDER: S-EPMC10543271 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature