Noninvasive low-level tragus stimulation attenuates inflammation and oxidative stress in acute heart failure.

ABSTRACT:

Purpose

Acute decompensated heart failure is associated with inflammation, oxidative stress, and excess sympathetic drive. It is unknown if neuromodulation would improve inflammation and oxidative stress in acute heart failure. We, therefore, performed this proof-of-concept study to evaluate the effects of neuromodulation using noninvasive low-level Tragus stimulation on inflammation and oxidative stress in ADHF.

Methods

19 patients with ejection fraction < 40% were randomized to neuromodulation- 4 hours twice daily (6 AM-10 AM and 6 PM-10 PM) (n = 8) or sham stimulation (n = 11) during hospital admission. All patients received standard-of-care treatment. Blood samples were collected at admission and discharge. Serum cytokines were assayed using standard immunosorbent techni

SUBMITTER: Dasari T 

PROVIDER: S-EPMC10543293 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature