Multi-omics analysis reveals the interaction of gut microbiome and host microRNAs in ulcerative colitis.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract that co-occurs with gut microbiota dysbiosis; however, its etiology remains unclear. MicroRNA (miRNA)-microbiome interactions play an essential role in host health and disease.

Methods

To investigate the gut microbiome and host miRNA profiles in colitis, we used a Dextran Sulfate Sodium (DSS)-induced ulcerative colitis (UC) model. Metagenomic sequencing and metabolome profiling were performed to explore typical microbiota and metabolite signatures in colitis, whereas mRNA and miRNA sequencing were used to determine differentially expressed miRNAs and their target genes in the inflamed colon.

Results

A total of 986 miRNAs were identified between the two groups, with 41 u

SUBMITTER: Ma L 

PROVIDER: S-EPMC10543339 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature