Optimizing therapeutic decision-making for off-label medicines use: A scoping review and consensus recommendations for improving practice and research^.

ABSTRACT:

Purpose

Off-label medicines use is a common and sometimes necessary practice in many populations, with important clinical, ethical and financial consequences, including potential unintended harm or lack of effectiveness. No internationally recognized guidelines exist to aid decision-makers in applying research evidence to inform off-label medicines use. We aimed to critically evaluate current evidence informing decision-making for off-label use and to develop consensus recommendations to improve future practice and research.

Methods

We conducted a scoping review to summarize the literature on available off-label use guidance, including types, extent and scientific rigor of evidence incorporated. Findings informed the development of consensus recommendations by an internation

SUBMITTER: Gazarian M 

PROVIDER: S-EPMC10543391 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature