Investigating cerebral perfusion with high resolution hyperpolarized [1-¹³ C]pyruvate MRI.

ABSTRACT:

Purpose

To investigate high-resolution hyperpolarized (HP) ¹³ C pyruvate MRI for measuring cerebral perfusion in the human brain.

Methods

HP [1-¹³ C]pyruvate MRI was acquired in five healthy volunteers with a multi-resolution EPI sequence with 7.5 × 7.5 mm² resolution for pyruvate. Perfusion parameters were calculated from pyruvate MRI using block-circulant singular value decomposition and compared to relative cerebral blood flow calculated from arterial spin labeling (ASL). To examine regional perfusion patterns, correlations between pyruvate and ASL perfusion were performed for whole brain, gray matter, and white matter voxels.

Results

High resolution 7.5 × 7.5 mm² pyruvate images were used to obtain relative cerebral bloo

SUBMITTER: Hu JY 

PROVIDER: S-EPMC10543485 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature