DNA methylation-based subtypes of acute myeloid leukemia with distinct prognosis and clinical features.

ABSTRACT: Acute myeloid leukemia (AML) is a malignancy of the stem cell precursors of the myeloid lineage. DNA methylation is an important DNA modification that regulates gene expression. Investigating AML heterogeneity based on DNA methylation could be clinically informative for improving clinical diagnosis and prognosis. The AML subtypes based on DNA methylation were identified by unsupervised consensus clustering. The association of these subtypes with gene mutation, copy number variations, immune infiltration and clinical features were further explored. Finally, univariate, LASSO and multivariate cox regression analyses were used to identify prognosis-associated genes and construct risk model for AML patients. In addition, we validated this model by using other datasets and explored the involved

SUBMITTER: Jian J 

PROVIDER: S-EPMC10543573 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature