The relationship of peritubular capillary density with glomerular volume and kidney function in living kidney donors.

ABSTRACT:

Background

Peritubular capillary rarefaction plays an important role in the progression of chronic kidney disease. Little is known about the relation between peritubular capillary density, glomerular volume and filtration rate in the healthy kidney.

Methods

In this single-center study, we included 69 living kidney donors who donated between 2005 and 2008 and had representative renal biopsies available. In all donors, glomerular filtration rate was measured using ¹²⁵I-Iothalamate before donation and at five years after donation. Before donation, the increase in glomerular filtration rate after dopamine stimulation was measured. Glomerular volume and peritubular capillary density were determined in biopsies taken at the time of transplantation. Pearson's correlation

SUBMITTER: van der Weijden J 

PROVIDER: S-EPMC10543576 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature