The normal distribution of the hypoxic ventilatory response and methodological impacts: a meta-analysis and computational investigation.

ABSTRACT: The hypoxic ventilatory response (HVR) is the increase in breathing in response to reduced arterial oxygen pressure. Over several decades, studies have revealed substantial population-level differences in the magnitude of the HVR as well as significant inter-individual variation. In particular, low HVRs occur frequently in Andean high-altitude native populations. However, our group conducted hundreds of HVR measures over several years and commonly observed low responses in sea-level populations as well. As a result, we aimed to determine the normal HVR distribution, whether low responses were common, and to what extent variation in study protocols influence these findings. We conducted a comprehensive search of the literature and examined the distributions of HVR values across 78 studies t

SUBMITTER: Oeung B 

PROVIDER: S-EPMC10543592 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature