Viral Evolution Shaped by Host Proteostasis Networks.

ABSTRACT: Understanding the factors that shape viral evolution is critical for developing effective antiviral strategies, accurately predicting viral evolution, and preventing pandemics. One fundamental determinant of viral evolution is the interplay between viral protein biophysics and the host machineries that regulate protein folding and quality control. Most adaptive mutations in viruses are biophysically deleterious, resulting in a viral protein product with folding defects. In cells, protein folding is assisted by a dynamic system of chaperones and quality control processes known as the proteostasis network. Host proteostasis networks can determine the fates of viral proteins with biophysical defects, either by assisting with folding or by targeting them for degradation. In this review, we dis

SUBMITTER: Yoon J 

PROVIDER: S-EPMC10543606 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature