Spatial and Spectral Components of the BOLD Global Signal in Rat Resting-State Functional MRI.

ABSTRACT:

Purpose

In resting-state fMRI (rs-fMRI), the global signal average captures widespread fluctuations related to unwanted sources of variance such as motion and respiration, as well as widespread neural activity; however, relative contributions of neural and non-neural sources to the global signal remain poorly understood. This study sought to tackle this problem through the comparison of the BOLD global signal to an adjacent non-brain tissue signal, where neural activity was absent, from the same rs-fMRI scan obtained from anesthetized rats. In this dataset, motion was minimal and ventilation was phase-locked to image acquisition to minimize respiratory fluctuations. Data were acquired using three different anesthetics: isoflurane, dexmedetomidine, and a combination of dexmedetomidi

SUBMITTER: Anumba N 

PROVIDER: S-EPMC10543609 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature