Experimenter administered Δ⁹-THC decreases nicotine self-administration in a rat model.

ABSTRACT:

Background

The co-use of nicotine and cannabis has been steadily rising in the United States. Rodent studies suggest that delta-9-tetrahydrocannabinol (THC) could increase addictive qualities of nicotine, but whether repeated THC exposure alters self-administration of nicotine has not been tested. We hypothesized that THC would increase the reinforcing effects of nicotine and alter nicotine intake.

Methods

Adult male and female Sprague-Dawley rats were treated with THC (0, 3, 30 mg/kg) daily for 14 days prior to and during training for intravenous self-administration of nicotine. Rats were allowed to self-administer nicotine for several weeks, then tested for sensitivity to nicotine dose through multiple determinations of a nicotine dose-effect curve with or without THC pret

SUBMITTER: Abraham AD 

PROVIDER: S-EPMC10543614 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature