Genome-wide Association Study Identifies Novel Risk Loci for Apical Periodontitis.

ABSTRACT:

Introduction

Apical periodontitis (AP) is a common consequence of root canal infection leading to periapical bone resorption. Microbial and host genetic factors and their interactions have been shown to play a role in AP development and progression. Variations in a few genes have been reported in association with AP; however, the lack of genome-wide studies has hindered progress in understanding the molecular mechanisms involved. Here, we report the first genome-wide association study of AP in a large and well-characterized population.

Methods

Male and female adults (n = 932) presenting with deep caries and AP (cases), or deep caries without AP (controls) were included. Genotyping was performed using the Illumina Expanded Multi-Ethnic Genotyping Array (MEGA). Single-variant

SUBMITTER: Petty LE 

PROVIDER: S-EPMC10543637 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature