Clustering of Ca_V 1.3 L-type calcium channels by Shank3.

ABSTRACT: Clustering of L-type voltage-gated Ca²⁺ channels (LTCCs) in the plasma membrane is increasingly implicated in creating highly localized Ca²⁺ signaling nanodomains. For example, neuronal LTCC activation can increase phosphorylation of the nuclear CREB transcription factor by increasing Ca²⁺ concentrations within a nanodomain close to the channel, without requiring bulk Ca²⁺ increases in the cytosol or nucleus. However, the molecular basis for LTCC clustering is poorly understood. The postsynaptic scaffolding protein Shank3 specifically associates with one of the major neuronal LTCCs, the Ca_V 1.3 calcium channel, and is required for optimal LTCC-dependent excitation-transcription coupling. Here, we co-expressed Ca_V 1.3 α1 subu

SUBMITTER: Yang Q 

PROVIDER: S-EPMC10543641 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature