Structural plasticity in the entorhinal and perirhinal cortices following hippocampal lesions in rhesus monkeys.

ABSTRACT: Immature neurons expressing the Bcl2 protein are present in various regions of the mammalian brain, including the amygdala and the entorhinal and perirhinal cortices. Their functional role is unknown but we have previously shown that neonatal and adult hippocampal lesions increase their differentiation in the monkey amygdala. Here, we assessed whether hippocampal lesions similarly affect immature neurons in the entorhinal and perirhinal cortices. Since Bcl2-positive cells were found mainly in areas Eo, Er, and Elr of the entorhinal cortex and in layer II of the perirhinal cortex, we also used Nissl-stained sections to determine the number and soma size of immature and mature neurons in layer III of area Er and layer II of area 36 of the perirhinal cortex. We found different structural chan

SUBMITTER: Villard J 

PROVIDER: S-EPMC10543642 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature