The modulation of iron metabolism affects the Rhabdomyosarcoma tumor growth in vitro and in vivo.

ABSTRACT: Rhabdomyosarcoma (RMS) is an aggressive rare neoplasm that derives from mesenchymal cells, which frequently develops resistance to the current therapies and the formation of metastases. Thus, new therapies are needed. The alteration of iron metabolism in cancer cells was effective in reducing the progression of many tumors but not yet investigated in RMS. Here we investigated the effect of iron modulation in RMS both in vitro and in vivo. We first characterized the most used RMS cell lines representing the most common subtypes, embryonal (ERMS, RD cells) and alveolar (ARMS, RH30 cells), for their iron metabolism, in basal condition and in response to its modulation. Then we investigated the effects of both iron overload and chelation strategies in vitro and in vivo. RMS cell lines expresse

SUBMITTER: Asperti M 

PROVIDER: S-EPMC10543952 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature