Prediagnostic Prescription Antibiotics Use and Survival in Patients with Colorectal Cancer: A Swedish National Register-Based Study.

ABSTRACT:

Background

Antibiotics use is associated with higher colorectal cancer risk, but little is known regarding any potential effects on survival.

Methods

We conducted a nationwide cohort study, using complete-population data from Swedish national registers between 2005 and 2020, to investigate prediagnostic prescription antibiotics use in relation to survival in colorectal cancer patients.

Results

We identified 36,061 stage I-III and 11,242 stage IV colorectal cancer cases diagnosed between 2010 and 2019. For stage I-III, any antibiotics use (binary yes/no variable) was not associated with overall or cancer-specific survival. Compared with no use, moderate antibiotics use (total 11-60 days) was associated with slightly better cancer-specific survival [adjusted HR (aHR) =

SUBMITTER: Lu SSM 

PROVIDER: S-EPMC10543975 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature