The influence of dual-energy computed tomography image noise in proton therapy treatment planning.

ABSTRACT:

Background and purpose

In proton therapy, a 3.5% margin is often used to account for proton range uncertainties, of which computed tomography (CT) image noise is assumed to contribute 0.5%. This work evaluates the noise-sensitivity of three dual-energy computed tomography (DECT)-based methods for mapping proton stopping power relative to water (SPR): Näsmark & Andersson (N&A), Landry-Saito (L-S), and the commercial application DirectSPR.

Methods and materials

DECT image data of a CIRS-062M phantom was acquired with CT scanners from two different vendors. Acquisitions were repeated 30 times to account for intra- and inter-scan variations. SPR maps were generated with the three DECT-based methods and range simulated in a commercial treatment planning system.

Results

Noi

SUBMITTER: Nasmark T 

PROVIDER: S-EPMC10544042 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature