PCSK9 Promotes Hypoxia-Induced EC Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia.
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ABSTRACT:
SUBMITTER: Zhang M
PROVIDER: S-EPMC10544082 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
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PCSK9 Promotes Hypoxia-Induced EC Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia.
Zhang Meixin M Chen Yixi Y Qiu Yumin Y Sun Jiapan J He Jiang J Liu Zhefu Z Shi Jian J Wei Wenbin W Wu Guifu G Liang Jianwen J
JACC. Basic to translational science 20230830 9
Hypoxia-induced endothelial cell death and impaired angiogenesis are the main pathophysiological features of critical limb ischemia. Mechanistically, proprotein convertase subtilisin/kexin type 9 (PCSK9) promoted Smac translocation from mitochondria to the cytoplasm. Inhibition of Smac release into the cytoplasm attenuated PCSK9-mediated hypoxia-induced pyroptosis. Functionally, PCSK9 overexpression impaired angiogenesis in vitro and reduced blood perfusion in mice with lower limb ischemia, but ...[more]
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