TDP-43 pathology is associated with increased tau burdens and seeding.

ABSTRACT:

Background

Most Alzheimer's Disease (AD) cases also exhibit limbic predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC), besides amyloid-β plaques and neurofibrillary tangles (NFTs) containing hyperphosphorylated tau (p-tau). LATE-NC is characterized by cytoplasmic aggregates positive for pathological TDP-43 and is associated with more severe clinical outcomes in AD, compared to AD cases lacking TDP-43 pathology TDP-43: AD(LATE-NC-). Accumulating evidence suggests that TDP-43 and p-tau interact and exhibit pathological synergy during AD pathogenesis. However, it is not yet fully understood how the presence of TDP-43 affects p-tau aggregation in symptomatic AD.

Methods

In this study, we investigated the impact of TDP-43 proteinopathy on p-tau path

SUBMITTER: Tome SO 

PROVIDER: S-EPMC10544192 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature