Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells.

ABSTRACT: Maternal decidual CD8+ T cells must integrate the antithetical demands of providing immunity to infection while maintaining immune tolerance for fetal and placental antigens. Human decidual CD8+ T cells were shown to be highly differentiated memory T cells with mixed signatures of dysfunction, activation, and effector function. However, no information is present on how specificity for microbial or fetal antigens relates to their function or dysfunction. In addition, a key question, whether decidual CD8+ T cells include unique tissue-resident memory T cells (Trm) or also effector memory T cell (Tem) types shared with peripheral blood populations, is unknown. Here, high-dimensional flow cytometry of decidual and blood CD8+ T cells identified 2 Tem populations shared in blood and decidua and

SUBMITTER: Mahajan S 

PROVIDER: S-EPMC10544202 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature