Loss of Farnesoid X receptor (FXR) accelerates dysregulated glucose and renal injury in db/db mice.

ABSTRACT:

Background

End-stage renal disease is primarily caused by diabetic kidney disease (DKD). The Farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, has anti-inflammatory, lipid-lowering and hypoglycemic properties. It also inhibits renal fibrosis. Although its physiological role is not fully understood, it also plays a role in the control of diabetic nephropathy (DN).

Methods

In the present study, we examined male FXR & leptin receptor double knockout mice, in which weight, blood glucose, body fat, and other indicators were monitored. After 6 months of rearing, blood and urine samples were collected and biochemical parameters were measured. Fibrosis was assessed by Masson's stain, while the assessment of the resuscitation case's condition was performed usi

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC10544308 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature