M6A methylation modification in autoimmune diseases, a promising treatment strategy based on epigenetics.

ABSTRACT:

Background

N6-methyladenosine (m6A) methylation modification is involved in the regulation of various biological processes, including inflammation, antitumor, and antiviral immunity. However, the role of m6A modification in the pathogenesis of autoimmune diseases has been rarely reported.

Methods

Based on a description of m6A modification and the corresponding research methods, this review systematically summarizes current insights into the mechanism of m6A methylation modification in autoimmune diseases, especially its contribution to rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).

Results

By regulating different biological processes, m6A methylation is involved in the pathogenesis of autoimmune diseases and provides a promising biomarker for the di

SUBMITTER: Huang Y 

PROVIDER: S-EPMC10544321 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature