Ubiquitination of the protocadherin-γA3 variable cytoplasmic domain modulates cell-cell interaction.

ABSTRACT: The family of ∼60 clustered protocadherins (Pcdhs) are cell adhesion molecules encoded by a genomic locus that regulates expression of distinct combinations of isoforms in individual neurons resulting in what is thought to be a neural surface "barcode" which mediates same-cell interactions of dendrites, as well as interactions with other cells in the environment. Pcdh mediated same-cell dendrite interactions were shown to result in avoidance while interactions between different cells through Pcdhs, such as between neurons and astrocytes, appear to be stable. The cell biological mechanism of the consequences of Pcdh based adhesion is not well understood although various signaling pathways have been recently uncovered. A still unidentified cytoplasmic regulatory mechanism might contribute to

SUBMITTER: Ptashnik A 

PROVIDER: S-EPMC10544333 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature