The miRNA transcriptome of cerebrospinal fluid in preterm infants reveals the signaling pathways that promote reactive gliosis following cerebral hemorrhage.

ABSTRACT:

Introduction

Germinal Matrix-Intraventricular Haemorrhage (GM-IVH) is one of the most common neurological complications in preterm infants, which can lead to accumulation of cerebrospinal fluid (CSF) and is a major cause of severe neurodevelopmental impairment in preterm infants. However, the pathophysiological mechanisms triggered by GM-IVH are poorly understood. Analyzing the CSF that accumulates following IVH may allow the molecular signaling and intracellular communication that contributes to pathogenesis to be elucidated. Growing evidence suggests that miRs, due to their key role in gene expression, have a significant utility as new therapeutics and biomarkers.

Methods

The levels of 2,083 microRNAs (miRs) in 15 CSF samples from 10 infants with IVH were measured using mi

SUBMITTER: Gialeli A 

PROVIDER: S-EPMC10544345 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature