Pathway2Targets: an open-source pathway-based approach to repurpose therapeutic drugs and prioritize human targets.

ABSTRACT:

Background

Recent efforts to repurpose existing drugs to different indications have been accompanied by a number of computational methods, which incorporate protein-protein interaction networks and signaling pathways, to aid with prioritizing existing targets and/or drugs. However, many of these existing methods are focused on integrating additional data that are only available for a small subset of diseases or conditions.

Methods

We have designed and implemented a new R-based open-source target prioritization and repurposing method that integrates both canonical intracellular signaling information from five public pathway databases and target information from public sources including OpenTargets.org. The Pathway2Targets algorithm takes a list of significant pathways as inpu

SUBMITTER: Dobbs Spendlove M 

PROVIDER: S-EPMC10544355 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature