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ABSTRACT: Background
Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the formation of atherosclerosis and metabolic syndrome. The lipid metabolic state in ITP patients is still unknown.Methods
We retrospectively reviewed 302 hospitalized ITP patients in our cohort, comparing their blood lipids, bleeding symptoms, metabolic diseases and treatment responses.Results
We found a high proportion of ITP patients suffered from hyperlipidemia, and other metabolic diseases including cardiovascular or cerebral atherosclerosis or infarction, hypertension, and type 2 diabetes. Hyperlipidemia was associated with severe bleeding and treatment refractoriness in ITP. Statins could alleviate thrombocytopenia and bleeding severity, and facilitate ITP treatment, while improving hyperlipidemia in ITP patients.Conclusions
Our present study demonstrated that lipid metabolism might play an indispensable role in ITP pathogenesis and development.
SUBMITTER: Han S
PROVIDER: S-EPMC10544441 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Han Shouqing S Lu Hui H Yu Yafei Y Liu Xinguang X Jing Fangmiao F Wang Liang L Zhao Yajing Y Hou Ming M
Thrombosis journal 20231002 1
<h4>Background</h4>Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the formation of atherosclerosis and metabolic syndrome. The lipid metabolic state in ITP patients is still unknown.<h4>Methods</h4>We retrospectively reviewed 302 hospitalized ITP patients in our coh ...[more]