Meiotic and mitotic aneuploidies drive arrest of in vitro fertilized human preimplantation embryos.

ABSTRACT:

Background

The high incidence of aneuploidy in early human development, arising either from errors in meiosis or postzygotic mitosis, is the primary cause of pregnancy loss, miscarriage, and stillbirth following natural conception as well as in vitro fertilization (IVF). Preimplantation genetic testing for aneuploidy (PGT-A) has confirmed the prevalence of meiotic and mitotic aneuploidies among blastocyst-stage IVF embryos that are candidates for transfer. However, only about half of normally fertilized embryos develop to the blastocyst stage in vitro, while the others arrest at cleavage to late morula or early blastocyst stages.

Methods

To achieve a more complete view of the impacts of aneuploidy, we applied low-coverage sequencing-based PGT-A to a large series (n = 909) of

SUBMITTER: McCoy RC 

PROVIDER: S-EPMC10544495 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature