Influence of affective states on informant impression of neuropsychiatric symptoms in people living with MCI.

ABSTRACT: Objectives: Alzheimer's disease (AD) and mild cognitive impairment (MCI) are often accompanied by neuropsychiatric symptoms (NPS; e.g. depression/apathy/irritability) causing challenges for people living with dementia/caregivers and predicting worse disease progression. Accurately assessing NPS is critical to research on AD/MCI. However, there are limitations to both self-reports and clinician evaluations; the field often relies on informants to assess NPS. Informants' perception of NPS are influenced by disease and caregiver factors that may lead to biased assessments. We aimed to assess the relationship between participants self-reported affective states (valence/arousal) and informant-reported NPS.Methods: Data from a double-blinded intervention design (primarily testing n

SUBMITTER: Therrien S 

PROVIDER: S-EPMC10544672 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature