Maternal whole blood mRNA signatures identify women at risk of early preeclampsia: a longitudinal study.

ABSTRACT:

Purpose

To determine whether previously established mRNA signatures are predictive of early preeclampsia when evaluated by maternal cellular transcriptome analysis in samples collected before clinical manifestation.

Materials and methods

We profiled gene expression at exon-level resolution in whole blood samples collected longitudinally from 49 women with normal pregnancy (controls) and 13 with early preeclampsia (delivery <34 weeks of gestation). After preprocessing and removal of gestational age-related trends in gene expression, data were converted into Z-scores based on the mean and standard deviation among controls for six gestational-age intervals. The average Z-scores of mRNAs in each previously established signature considered herein were compared between cases and c

SUBMITTER: Tarca AL 

PROVIDER: S-EPMC10544754 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature