Coupling of activity, metabolism and behaviour across the Drosophila brain.

ABSTRACT: Coordinated activity across networks of neurons is a hallmark of both resting and active behavioural states in many species^1-5. These global patterns alter energy metabolism over seconds to hours, which underpins the widespread use of oxygen consumption and glucose uptake as proxies of neural activity^6,7. However, whether changes in neural activity are causally related to metabolic flux in intact circuits on the timescales associated with behaviour is unclear. Here we combine two-photon microscopy of the fly brain with sensors that enable the simultaneous measurement of neural activity and metabolic flux, across both resting and active behavioural states. We demonstrate that neural activity drives changes in metabolic flux, creating a tight coupling between these sign

SUBMITTER: Mann K 

PROVIDER: S-EPMC10544789 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature