Spindle positioning and its impact on vertebrate tissue architecture and cell fate.

ABSTRACT: In multicellular systems, oriented cell divisions are essential for morphogenesis and homeostasis as they determine the position of daughter cells within the tissue and also, in many cases, their fate. Early studies in invertebrates led to the identification of conserved core mechanisms of mitotic spindle positioning centred on the Gα_i-LGN-NuMA-dynein complex. In recent years, much has been learnt about the way this complex functions in vertebrate cells. In particular, studies addressed how the Gα_i-LGN-NuMA-dynein complex dynamically crosstalks with astral microtubules and the actin cytoskeleton, and how it is regulated to orient the spindle according to cellular and tissue-wide cues. We have also begun to understand how dynein motors and actin regulators interact wit

SUBMITTER: Lechler T 

PROVIDER: S-EPMC10544824 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature