Hyperfibrinolysis drives mechanical instabilities in a simulated model of trauma induced coagulopathy.

ABSTRACT:

Introduction

Trauma induced coagulopathy (TIC) is common after severe trauma, increasing transfusion requirements and mortality among patients. TIC has several phenotypes, with primary hyperfibrinolysis being among the most lethal. We aimed to investigate the contribution of hypercoagulation, hemodilution, and fibrinolytic activation to the hyperfibrinolytic phenotype of TIC, by examining fibrin formation in a plasma-based model of TIC. We hypothesized that instabilities arising from TIC will be due primarily to increased fibrinolytic activation rather than hemodilution or tissue factor (TF) induced hypercoagulation.

Methods

The influence of TF, hemodilution, fibrinogen consumption, tissue plasminogen activator (tPA), and the antifibrinolytic tranexamic acid (TXA) on plasma

SUBMITTER: Gosselin AR 

PROVIDER: S-EPMC10544892 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature