Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling.

ABSTRACT:

Background

Intervertebral disc degeneration (IVDD) is a leading cause of low back pain (LBP). The pathological process of IVDD is associated with inflammatory reactions and extracellular matrix (ECM) disorders. Digoxin is widely used for treating heart failure, and it has been reported to have anti-inflammatory effects.

Objective

This study is to investigate the role of digoxin in the pathogenesis of intervertebral disc degeneration as well as the involved molecular mechanism, particularly the potential target protein.

Methods

We exploited a rat needle model to investigate digoxin's role in intervertebral disc degeneration in vivo. Safranin O staining was used to measure cartilaginous tissue in the intervertebral disc. The morphological changes of intervertebra

SUBMITTER: Meng Q 

PROVIDER: S-EPMC10544936 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature