Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression.

ABSTRACT: Introduction: Although various therapies have been adopted to treat cancer, metastasis of tumor cells still is a big challenge that compromises therapeutic benefits. Methods: We herein report an injectable drug-loaded hybrid hydrogel that can achieve sonodynamic therapy (SDT) and chemodyanmic therapy (CDT) combined action and suppression of tumor metastasis. This alginate (ALG)-based hydrogel (termed as AMPS) contains manganese dioxide (MnO₂) nanoparticles as the CDT agents, an organic polymer as the sonosensitizer, and a SIS3 drug as metastasis inhibitor. Results: AMPS is formed via the chelation of ALG by Ca²⁺ in tumor microenvironment, in which MnO₂ nanoparticles mediate CDT via Fenton-like reaction and the organic polymers enable SD

SUBMITTER: Wang X 

PROVIDER: S-EPMC10544978 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature