Dissecting the association between gut microbiota and liver cancer in European and East Asian populations using Mendelian randomization analysis.

ABSTRACT:

Background

Ample evidence suggests an important role of the gut microbiome in liver cancer, but the causal relationship between gut microbiome and liver cancer is unclear. This study employed Mendelian randomization (MR) analysis to examine the causal relationship between the gut microbiome and liver cancer in European and East Asian populations.

Methods

We sourced genetic variants linked to gut microbiota from the MiBioGen consortium meta-analysis, and procured liver cancer genome-wide association study (GWAS) summary data from the FinnGen consortium and Biobank Japan. We employed the inverse variance weighted method for primary statistical analysis, fortified by several sensitivity analyses such as MR-PRESSO, MR-Egger regression, weighted median, weighted mode, and maximum

SUBMITTER: Jiang H 

PROVIDER: S-EPMC10544983 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature