Identification of differential immune cells and related diagnostic genes in patients with diabetic retinopathy.

ABSTRACT:

Background

Diabetic retinopathy (DR) is a frequent microvascular abnormality associated with diabetes mellitus. The loss of retinal immunity is an important underlying mechanism of the DR pathogenesis, including the change in retinal immunosuppressive characteristics and the blood-retinal barrier disturbances. Therefore, this investigation screens immune-associated biomarkers in the retina of DR patients.

Methods

In this investigation, the differential expression genes (DEGs) were acquired from Gene Expression Omnibus data GSE102485. The relative expression of 22 immune cell types in each sample was calculated by CIBERSORT analysis based on gene expression profile. The core module closely associated with immune infiltration was also screened by weighted gene co-expression ne

SUBMITTER: Yuan L 

PROVIDER: S-EPMC10545100 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature