Association between genetically proxied HMGCR inhibition and male reproductive health: A Mendelian randomization study.

ABSTRACT:

Background

The causal associations between statin use and male sex hormone levels and related disorders have not been fully understood. In this study, we employed Mendelian randomization for the first time to investigate these associations.

Methods

In two-sample Mendelian randomization framework, genetic proxies for hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) inhibition were identified as variants in the HMGCR gene that were associated with both levels of gene expression and low density lipoprotein cholesterol (LDL-C). We assessed the causal relationship between HMGCR inhibitor and 5 sex hormone levels/2 male-related diseases. Additionally, we investigated the association between 4 circulating lipid traits and outcomes. The "inverse variance weighting" method was u

SUBMITTER: Yan Z 

PROVIDER: S-EPMC10545124 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature