Identification of a basement membrane-related genes signature to predict prognosis, immune landscape and guide therapy in gastric cancer.

ABSTRACT: The basement membrane is an essential defense against cancer progression and is intimately linked to the tumor immune microenvironment. However, there is limited research comprehensively discussing the potential application of basement membrane-related genes (BMRGs) in the prognosis evaluation and immunotherapy of gastric cancer (GC). The RNA-seq data and clinical information of GC patients were collected from the TCGA and GEO database. Prognosis-associated BMRGs were filtered via univariate Cox regression analysis. The 4-BMRGs signatures were constructed by lasso regression. Prognostic predictive accuracy of the 4-BMRGs signature was appraised with survival analysis, receiver operating characteristic curves, and nomogram. Gene set enrichment analysis (GSEA), gene ontology, and gene set va

SUBMITTER: Liu ZY 

PROVIDER: S-EPMC10545384 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature