Longitudinal developmental trajectories of functional connectivity reveal regional distribution of distinct age effects in infancy.

ABSTRACT: Prior work has shown that different functional brain networks exhibit different maturation rates, but little is known about whether and how different brain areas may differ in the exact shape of longitudinal functional connectivity growth trajectories during infancy. We used resting-state functional magnetic resonance imaging (fMRI) during natural sleep to characterize developmental trajectories of different regions using a longitudinal cohort of infants at 3 weeks (neonate), 1 year, and 2 years of age (n = 90; all with usable data at three time points). A novel whole brain heatmap analysis was performed with four mixed-effect models to determine the best fit of age-related changes for each functional connection: (i) growth effects: positive-linear-age, (ii) emergent effects: positive-log-

SUBMITTER: Liu J 

PROVIDER: S-EPMC10545442 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature