Comprehension of acoustically degraded speech in Alzheimer's disease and primary progressive aphasia.

ABSTRACT: Successful communication in daily life depends on accurate decoding of speech signals that are acoustically degraded by challenging listening conditions. This process presents the brain with a demanding computational task that is vulnerable to neurodegenerative pathologies. However, despite recent intense interest in the link between hearing impairment and dementia, comprehension of acoustically degraded speech in these diseases has been little studied. Here we addressed this issue in a cohort of 19 patients with typical Alzheimer's disease and 30 patients representing the three canonical syndromes of primary progressive aphasia (non-fluent/agrammatic variant primary progressive aphasia; semantic variant primary progressive aphasia; logopenic variant primary progressive aphasia), compared

SUBMITTER: Jiang J 

PROVIDER: S-EPMC10545509 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature