AKR1B10 regulates M2 macrophage polarization to promote the malignant phenotype of gastric cancer.

ABSTRACT:

Background

Immunotherapy has brought new hope to gastric cancer (GC) patients. Exploring the immune infiltration pattern in GC and the key molecules is critical for optimizing the efficacy of immunotherapy. Aldo-keto reductase family 1 member B10 (AKR1B10) is an inflammatory regulator and is closely related to the prognosis of patients with GC. However, the function of AKR1B10 in GC remains unclear.

Methods

In the present study, the CIBERSORT algorithm was used to analyze the immune infiltration pattern in 373 samples in the Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) were seared by combing the TCGA database and the Gene Expression Omnibus (GEO) database, and the key molecule AKR1B10 was identified by weighted gene coexpression network analysis

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10545534 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature