Ontology highlight
ABSTRACT:
SUBMITTER: Krapacher FA
PROVIDER: S-EPMC10545536 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Krapacher Favio A FA Fernández-Suárez Diana D Andersson Annika A Carrier-Ruiz Alvaro A Ibáñez Carlos F CF
The EMBO journal 20220622 15
ΔfosB is an alternatively spliced product of the FosB gene that is essential for dopamine-induced reward pathways and that acts as a master switch for addiction. However, the molecular mechanisms of its generation and regulation by dopamine signaling are unknown. Here, we report that dopamine D1 receptor signaling synergizes with the activin/ALK4/Smad3 pathway to potentiate the generation of ΔFosB mRNA in medium spiny neurons (MSNs) of the nucleus accumbens (NAc) via activation of the RNA-bindin ...[more]