Unique functional responses differentially map onto genetic subtypes of dopamine neurons.

ABSTRACT: Dopamine neurons are characterized by their response to unexpected rewards, but they also fire during movement and aversive stimuli. Dopamine neuron diversity has been observed based on molecular expression profiles; however, whether different functions map onto such genetic subtypes remains unclear. In this study, we established that three genetic dopamine neuron subtypes within the substantia nigra pars compacta, characterized by the expression of Slc17a6 (Vglut2), Calb1 and Anxa1, each have a unique set of responses to rewards, aversive stimuli and accelerations and decelerations, and these signaling patterns are highly correlated between somas and axons within subtypes. Remarkably, reward responses were almost entirely absent in the Anxa1⁺ subtype, which instead displayed ac

SUBMITTER: Azcorra M 

PROVIDER: S-EPMC10545540 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature