Surface proteome of plasma extracellular vesicles as mechanistic and clinical biomarkers for malaria.

ABSTRACT:

Purpose

Malaria is a life-threatening mosquito-borne disease caused by Plasmodium parasites, mainly in tropical and subtropical countries. Plasmodium falciparum (P. falciparum) is the most prevalent cause on the African continent and responsible for most malaria-related deaths globally. Important medical needs are biomarkers for disease severity or disease outcome. A potential source of easily accessible biomarkers are blood-borne small extracellular vesicles (sEVs).

Methods

We performed an EV Array to find proteins on plasma sEVs that are differentially expressed in malaria patients. Plasma samples from 21 healthy subjects and 15 malaria patients were analyzed. The EV array contained 40 antibodies to capture sEVs, which were then visualized with a cocktail of biotin-conjuga

SUBMITTER: Jung AL 

PROVIDER: S-EPMC10545645 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature