CHD8 regulates gut epithelial cell function and affects autism-related behaviors through the gut-brain axis.

ABSTRACT: Autism is a neurodevelopmental disorder characterized by early-onset social behavioral deficits and repetitive behaviors. Chromodomain helicase DNA-binding protein (CHD8) is among the genes most strongly associated with autism. In addition to the core behavioral symptoms of autism, affected individuals frequently present with gastrointestinal symptoms that are also common among individuals harboring mutations in the gene encoding CHD8. However, little is known regarding the mechanisms whereby CHD8 affects gut function. In addition, it remains unknown whether gastrointestinal manifestations contribute to the behavioral phenotypes of autism. The current study found that mice haploinsufficient for the large isoform of Chd8 (Chd8L) exhibited increased intestinal permeability, transcriptomic dy

SUBMITTER: Chatterjee I 

PROVIDER: S-EPMC10545671 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature