Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC10545698 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Wang Guoli G He Xin X Dai Huiqi H Lin Lingyi L Cao Wenmin W Fu Yao Y Diao Wenli W Ding Meng M Zhang Qing Q Chen Wei W Guo Hongqian H
Oncogenesis 20231002 1
Lymph node (LN) metastasis is one of the key prognostic factors in bladder cancer, but its underlying mechanisms remain unclear. Here, we found that elevated expression of WD repeat domain 4 (WDR4) in bladder cancer correlated with worse prognosis. WDR4 can promote the LN metastasis and proliferation of bladder cancer cells. Mechanistic studies showed that WDR4 can promote the nuclear localization of DEAD-box helicase 20 (DDX20) and act as an adaptor to bind DDX20 and Early growth response 1 (Eg ...[more]