A coordinate-based meta-analysis of human amygdala connectivity alterations related to early life adversities.

ABSTRACT: By affecting core neurobiological systems early in development, early life adversities (ELAs) might confer latent vulnerability to future psychopathologies. This coordinate-based meta-analysis aims to identify significant convergent alterations in functional connectivity of the amygdala related to ELAs across resting-state and task-based fMRI-studies. Five electronic databases were systematically searched until 22 October 2020, retrieving 49 eligible studies (n = 3162 participants). Convergent alterations in functional connectivity related to ELAs between the amygdala and the anterior cingulate cortex (ACC) and left hippocampus were found. Sub-analyses based on hemisphere and direction showed that connectivity seeded in the right amygdala was affected and, moreover, revealed that connectiv

SUBMITTER: Kraaijenvanger EJ 

PROVIDER: S-EPMC10545708 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature