Estimating the contribution of CD4 T cell subset proliferation and differentiation to HIV persistence.

ABSTRACT: Persistence of HIV in people living with HIV (PWH) on suppressive antiretroviral therapy (ART) has been linked to physiological mechanisms of CD4+ T cells. Here, in the same 37 male PWH on ART we measure longitudinal kinetics of HIV DNA and cell turnover rates in five CD4 cell subsets: naïve (T_N), stem-cell- (T_SCM), central- (T_CM), transitional- (T_TM), and effector-memory (T_EM). HIV decreases in T_TM and T_EM but not in less-differentiated subsets. Cell turnover is ~10 times faster than HIV clearance in memory subsets, implying that cellular proliferation consistently creates HIV DNA. The optimal mathematical model for these integrated data sets posits HIV DNA also passages between CD4 cell subsets via cellular diff

SUBMITTER: Reeves DB 

PROVIDER: S-EPMC10545742 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature