Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis.

ABSTRACT: Patients with rheumatoid arthritis (RA) have a much higher incidence of cardiac dysfunction, which contributes to the high mortality rate of RA despite anti-arthritic drug therapy. In this study, we investigated dynamic changes in cardiac function in classic animal models of RA and examined the potential effectors of RA-induced heart failure (HF). Collagen-induced arthritis (CIA) models were established in rats and mice. The cardiac function of CIA animals was dynamically monitored using echocardiography and haemodynamics. We showed that cardiac diastolic and systolic dysfunction occurred in CIA animals and persisted after joint inflammation and that serum proinflammatory cytokine (IL-1β, TNF-α) levels were decreased. We did not find evidence of atherosclerosis (AS) in arthritic animals ev

SUBMITTER: Zhu ZD 

PROVIDER: S-EPMC10545746 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature